The Iyo-Matsuyama Domain (伊予松山藩 Iyo-Matsuyama han ) was a Japanese domain of the Edo period, with its holdings centered in modern-day Matsuyama, Ehime.
The Iyo-Matsuyama domain passed through several hands before settling as the fief of a branch of the Hisamatsu-Matsudaira. In the Bakumatsu period, the domain took part in the Tokugawa shogunate's military campaign against Chōshū. During the Boshin War, Iyo-Matsuyama sided with the Kyoto government. The domain was disbanded in 1871.
Harada Sanosuke of the Shinsengumi was the son of a low-ranking Iyo-Matsuyama retainer.